Program agenda 2011

1. In vivo phenotyping of mutant rodents:

Integrating neural activity, neurochemistry, heart rate & behavior
Aim of the course is to promote advanced phenotyping of mutant rodents models with a focus on models of psychopathology. Current topics are presented and ample experimental experience will be provided for several state-of-the-art techniques and analyses for an advanced course combining both theoretical aspects and practical approaches.

Guest speakers besides the organizers:
Karl Deisseroth, Stanford University, Stanford, USA
Bart Ellenbroek, Victoria University of Wellington, New Zealand
Ilan Golani, Tel Aviv University, Israel
Cornelius Gross EMBL, Monterotondo/Rome, Italy
Stephan von Hörsten, University Erlangen-Nürnberg, Germany
Martien J.H. Kas, University Medical Center Utrecht, Netherlands
Antonnius B. Mulder, VU University Medical Center, Amsterdam, Netherlands
Paul E.M. Philipps, University of Washington, Seattle, USA
Sabine Spijker, VU University Amsterdam, Netherlands
Per Svenningsson, Karolinska Institutet, Stockholm, Sweden
Joost Verhaagen, Netherlands Institute for Neuroscience, Amsterdam, Netherlands
Taco J. de Vries, VU University Medical Center, Amsterdam, Netherlands
Catharine A. Winstanley, University of British Columbia, Vancouver, Canada
Mirjam leloux, Interactive webinar on valorisation, the Netherlands

When: 22-27 August 2011
Where: VU University Amsterdam, The Netherlands
What: 5 day Postgraduate course for Ph.D. students and early post-docs interested in integrative approaches combining behavior with electrophysiologic, autonomic and neurochemical readouts under physiological conditions. (max. 20)

2. Molecular recognition and interaction analysis

The course will cover the basic features of molecular recognition and the application of such knowledge for research in the Life Sciences as well as for applications in drug discovery and molecular diagnostics. Methods for experimental and computational analysis of molecular interactions will be described and evaluated for different types of studies. Examples of how these can be used for characterization of interactions will be presented.

When: 7-9 December 2011
Where: Uppsala

3. Annual Meeting

When: 10 December 2011
Where: Uppsala

4. Neuropsychopharmacoly

Lectures concerning the role signal transduction cascades in relation to emotional learning, cognition and depression. Experimental parts where the participants will by introduced to biochemical methods of studying intracellular signalling with an emphasis on whole animal experiments. Behavioural methods to study emotional learning will also be presented and demonstrated.

When: 12-15 December 2011
Where: Stockholm

Below you can find a brief overview of all the courses and workhops of BrainTrain. Updates will be placed on the website regularly.

Courses

BrainTrain courses,workshops and conferences are open to students from outside the network. Each workshop is introduced by a mini-symposium on the topic by (inter)national speakers. Lecturers in the courses are from the BrainTrain consortium and invited speakers.

Introduction course in Neuroscience and Omics
Introduction in genetics, proteomics, and imaging as well as behaviour analyses related to brain diseases (3 days/VUmc & SYL).

Behavioral Neuroscience Data Analysis
Introduction to the Viewer Software and its customization to different needs in various behavior essays e.g. spatial learning tasks such as the holeboard test and the Barnes maze test. Synchronization with additional physiological measures such as ECG and neural activity(3 days/Bonn).

Fragment based drug discovery: From screening to design
Introduction in fragment based drug discovery. Overview of methods for design, screening, and optimization of fragment libraries fragment libraries for ligands against a certain target as well as computer-based modelling of the interactions (7 days, Beactica).

Molecular neuropharmacology techniques for behavioral phenotyping
Introduction to protein phosphorylation in vivo assays to monitor cognitive and emotional processes in mouse models (7 days, KI).

New optical and computational methods for investigating brain function
ntroduction to new optical and computational methods (neuroConstruct) to study brain function at the synaptic, neuronal and network level (3 days/UCL).

Functional analysis of synaptoneurosomes and local protein synthesis
Introduction to synaptoneurosomes preparation from different mouse brain areas. Isolation of synaptically localized mRNAs. Stimulation of synaptoneurosomes and study of local protein synthesis (4 days/KU Leuven).

Integrative neurobiology of cholinergic systems
Introduction to various effects of nicotine on behavior and electrophysiology by binding to different choline receptors, providing new concepts with pharmacological relevance implications for patients with Parkinson’s or Alzheimer disease(3 days/IP).

Workshops

BrainTrain courses, workshops and conferences are open to students from outside the network. Each workshop is introduced by a mini-symposium on the topic by (inter)national speakers. Lecturers in the courses are from the BrainTrain consortium and invited speakers.

Molecular imaging of neuronal cell surface molecules
Introduction of single particle tracking (SPT) and fluorescence recovery after photobleaching (FRAP); focus on synaptonuclear signalling and extracellular brain matrix (3 days/IfN).

Systems Neurobiology
Introduction to transcriptome structure, transcriptional network, epigenomics, and system biology of gene expression and nervous system function in combination with computational approach for drug design for Neurodegenerative diseases (3 days/SISSA).

Acute spatio-temporally controlled genetic perturbations of the brain in vivo
Introduction to viral gene transfer and stereotaxic delivery to rodent brain in vivo. Several viral systems (e.g. Sindbis, Adenovirus), application of fluorescent proteins/fusion proteins/tracers/beads/tags, and ultra-high precision stereotaxic procedures will be discussed and demonstrated along with detailed procedures on animal handling/anesthesia (7 days/UKL-HD).

Functional analysis of synaptoneurosomes and local protein synthesis
Introduction to synaptoneurosomes preparation from different mouse brain areas. Isolation of synaptically localized mRNAs. Stimulation of synaptoneurosomes and study of local protein synthesis (4 days/KU Leuven).

New tools for brain genomics, bioinformatics and system biology
Advanced methods as a follow up for W1 including neuronal genomics, bioinformatics and systems biology (7 days/RIKEN OSC).