Transfer of knowledge
The ability to have integrative multidisciplinary research is indispensable for a systematic genetic approach with functional significance and requires transfer-of-knowledge within each research team but also between research teams. Researchers will rotate among institutes, strengthening the cohesion within the research teams of the BrainTrain Consortium.
To ensure integration of the individual research teams in the overall research programme, there is substantial transfer of knowledge between the 5 research teams.
Based on the genetics and genomics studies performed by the research teams: Genetics of the brain, The synaptic interactome and Synaptic plasticity, several human and rodent candidate genes linked to brain disease will be identified.
In addition, research team Genetics of the brain and Synaptic plasticity will provide candidate genes that influence neural network properties. From this set of integrated data, viral vectors will be made for these genes.
Research team Functional genomic of the synapse, Synaptic plasticity and Transmission and behavioral function will use this viral vector for interference studies of gene expression at either the synaptic and network level or behavioral level.
Annual meetings and other shared activities, guarantee prominent knowledge transfer between researchers within the network but also exchange of knowledge with external experts in the field.
The figure shows the organization and research focus of the academic and industrial network partners within the 5 research teams.
Each research team contains 3 students hosted by each of the 3 network partners.
Arrows indicate knowledge transfer that takes place between the 5 research teams among network partner institutes, resulting in an assembly ‘train’ of data exchange.