The key objective of this Research Team was to study which candidate genes regulate synaptic delivery and whether neurodegenerative disease-linked variations in such genes, isolated in Genetics of the Brain, influence synaptic transport.
The research outlined in WP3 has yielded new insight in cell‐to‐cell communication in neuronal networks on multiple levels, ranging from intracellular mechanisms for neurotransmitter vesicle release in a single synapse to neuronal network activity in the intact brain of a live animal. By this multi‐disciplinary research of genetic models for neurodegenerative disease, this WP has delivered a deeper understanding of nerve‐cell connectivity, which forms the basis of learning and memory.
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Cell Biol, submitted. *These authors contributed equally.