Tag Archives: Synaptic plasticity

Research teams

Transfer of knowledge The ability to have integrative multidisciplinary research is indispensable for a systematic genetic approach with functional significance and requires transfer-of-knowledge within each research team but also between research teams. Researchers rotated among institutes, strengthening the cohesion within the research teams of the BrainTrain Consortium. There was substantial transfer of knowledge between the […]

Transmission / behaviour

Background The etiology of many disorders including age-related cognitive decline and neurodegenerative disorders such as dementia and Parkinson’s disease is still poorly understood. Fast neurotransmission and slower neuromodulation play major roles in synaptic plasticity underlying cognitive functions. The involvement of synaptic proteins in a spectrum of major brain diseases (synaptopathies) including neurodegenerative diseases and affective […]

Synaptic plasticity

Background In neuropsychiatric disorders associated with reduced cognitive abilities, such as age-related cognitive decline, but also mental retardation, the ability of synapses to alter their strength is strongly affected. As a result, information processing and neuronal network functioning is reduced, ultimately leading to cognitive decline and disability. In cognitive processing disorders of Alzheimer’s disease and […]

  • Events

    Training: students can apply for the oncoming courses and workshops >Read more

  • Video

  • JoVE video paper

    JoVE, the Journal of Visualized Experiments gives the opportunity to share a method with the science community by actually showing how to prepare and perform an experiment. We used the opportunity to create a video-methods paper of the well-established calcium imaging technique in immature brain slices.

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  • Research teams

    To reach its objectives, the BrainTrain research program is composed of 5 scientific Research Teams, see list below, with 3 trainees each.
  • Genetics of the brain

    The increasing prevalence for neurodegenerative disease in our aging population poses a growing problem for healthcare.
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  • The synaptic interactome

    Many brain disorders are to be considered 'synaptic diseases" or 'synaptopathies' and cellular function of synapses.
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  • Functional genomic of the synapse

    The synapse is a specialized structure between two neurons at which basal neuronal communication takes place.
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  • Synaptic plasticity

    In neuropsychiatric disorders associated with reduced cognitive abilities, such as age-related cognitive decline, but also mental retardation, the ability of synapses to alter their strength is strongly affected.
    >Read more
  • Transmission and behavioral function

    The etiology of many disorders including age-related cognitive decline and neurodegenerative disorders such as dementia and Parkinson’s disease is still poorly understood.
    >Read more