Transfer of knowledge The ability to have integrative multidisciplinary research is indispensable for a systematic genetic approach with functional significance and requires transfer-of-knowledge within each research team but also between research teams. Researchers will rotate among institutes, strengthening the cohesion within the research teams of the BrainTrain Consortium. To ensure integration of the individual research [...]
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Video
JoVE video paper
JoVE, the Journal of Visualized Experiments gives the opportunity to share a method with the science community by actually showing how to prepare and perform an experiment. We used the opportunity to create a video-methods paper of the well-established calcium imaging technique in immature brain slices.
The increasing prevalence for neurodegenerative disease in our aging population poses a growing problem for healthcare.
Many brain disorders are to be considered 'synaptic diseases" or 'synaptopathies' and cellular function of synapses.
The synapse is a specialized structure between two neurons at which basal neuronal communication takes place.
In neuropsychiatric disorders associated with reduced cognitive abilities, such as age-related cognitive decline, but also mental retardation, the ability of synapses to alter their strength is strongly affected.
The etiology of many disorders including age-related cognitive decline and neurodegenerative disorders such as dementia and Parkinson’s disease is still poorly understood.